Orange cats are not always male but 2 out of 3 are. It’s related to gender chromosomes. Female cats have two x chromosomes and male cats have an x and a y chromosome. Since male cats have one x chromosome, if that chromosome ends up having a dominant orange color, the cat will be orange. For a female cat to be orange, they would have to have dominant orange genes on both their x chromosomes. There is a 25% chance of that happening. Most orange cats are male; however there are also some that are female.