As popular use of the cactus extract Hoodia increases, so does the frequency at which people ask the question, does Hoodia affect blood pressure? And does hoodia gordonii cause high blood pressure? Nothing points to Hoodia causing high blood pressure at this time were affecting blood pressure at all. However, that it is wise to note that those with high blood pressure or individuals who are taking blood pressure medication are devised to avoid the usage of Hoodia due to potential for chemical interactions or other problems that might arise. Before taking Hoodia it is a good idea to speak to your doctor first.