Margarine contains no cholesterol as it is made from vegetable oil, an unsaturated fat. Incidentally, it is also high in `good’ fats – polyunsaturated and monounsaturated - that help reduce low-density lipoprotein and cholesterol level. In general, margarine is regarded as a heart-healthy spread and has less fat and calories per serving. But not all margarines are equal in terms of quality. That is, more solid the margarine, the more trans fat it may contain. Stick margarine usually has more trans fat than do tub margarine. Like saturated fat, trans fat also increases blood cholesterol and the risk of heart disease, the number one killer in the US.